A new open‑access publication, Clinical Manual of Palliative Care for Any Setting: Toward Universal Contextually‑Adapted Access, is now available. The manual provides guidance for adapting state-of-the-art symptom relief and psychosocial support to local cultural values, for combining palliative care with disease-directed treatment, and for integration of palliative care into healthcare systems. To maximize its usefulness in resource-limited settings where palliative care is least accessible and suffering most pervasive, it includes only medicines and equipment that are safe, effective, inexpensive, and widely available in most low- and middle-income countries. The manual is a product of the Program in Global Palliative Care at Harvard Medical School and its network of dedicated partners working in low- and middle-income settings toward universal access to palliative care.