This volume represents one of the fundamental GICR Hub activities, which is to provide regional reports on cancer to complement IARC’s role in publishing international cancer incidence data in its Cancer Incidence in Five Continents (CI5) series. This volume brings together results from 25 cancer registries in 20 sub-Saharan African countries, from time periods ranging from 1 to 10 years within the past two decades. Not all of these results will be of sufficient quality (i.e. completeness and/or validity) to qualify for inclusion in CHAPTER 1 Introduction 2 Introduction the next volume of the CI5 series. However, because AFCRN membership requires that registries meet minimum criteria for completeness of case ascertainment (> 70% of the cases expected in the area must be registered), the results are undoubtedly a reasonable reflection of the true cancer profile in their respective populations. The individual registry presentations (Chapter 4, p. 13) include commentary on specific factors that should be taken into account in interpreting the observations.